

Exhausted parental T cells
Black:Parental T Cell Clone (Exhausted)
Green:Antigen X positive tumors
(Black cells can not kill green cells well)
iPS-T
Black:iPSC-derived CD8a+b+T cells (Rejuvenated)
Green: Antigen X positive tumors
(Black cells kill green cells while
proliferating)
Molecular Therapy (2021), doi: https://doi.org/10.1016/ j.ymthe.2021.05.016.
Red : iPS-T specific to antigen X
Green: Tumor cells NOT expressing antigen X
(iPS-T patrols but does not attack
the tumor cells)
Red : iPS-T specific to antigen X
Green: Tumor cells expressing antigen X
(iPS-T attacks and eliminates
the tumor cells)
Cell Stem Cell | (2018) 23:1–9 | https://doi.org/10.1016/j.stem.2018.10.005
CD8αβ
Strong TCR signals
for antigen specific cytotoxicity
CD8αα
Insufficient TCR signals
for antigen specific cytotoxicity
Cell Stem Cell | (2018) 23:1–9 | https://doi.org/10.1016/j.stem.2018.10.005
Elongation of iPS-T‘s telomere
Correlation between the efficacy of T cell therapy
and the telomere length is reported.
Nat Rev Cancer | (2008) 8: 299–308 | https://doi.org/10.1038/nrc2355
iPS-T‘s high ability of proliferation
Exhausted T cells do not proliferate well,
while iPS-T shows massive growth
as naïve T cells do.
Patient’s exhausted T cell
When immune checkpoint receptors on
T cells are activated, cytotoxic responses of
T cells are suppressed.
iPS-T
As iPS-T cells express no/less
immune
check points receptors,
potent cytotoxic responses
against tumor cells are regained.